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Doctors say the restrictions can also affect diabetes patients who need to switch from other GLP-1 drugs or adjust doses for treatment reasons

Furthermore, the worsening of DR is short-lived: DR tends to improve within two years after initiation of treatment

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Studies of exposure, metabolism, and interactions must treat orforglipron as a CYP3A-metabolized small molecule considering hepatic clearance, potential drugdrug interactions, and oral-absorption variables rather than applying the peptidase-degradation and renal-handling framework appropriate to peptides