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DOI: 10.1056/NEJMoa2307563

Molecular mechanisms of ros production and oxidative stress in diabetes

[9] These targets can be adjusted based on individual capability and gradually increased as fitness improves

However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively