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Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)

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Dehydration: Gastrointestinal side effects can also lead to dehydration, contributing to muscle spasms and eye twitching

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Irritable bowel syndrome in adults: diagnosis and management (CG61) Recommendations

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Recently, reduced amounts of hypoxanthine have been reported in stool samples of patients with IBS-C and IBS-D (Mars et al., 2020)

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Always inject slowly down the vial wall

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