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In addition, other relevant therapies based on incretins, including GIP receptor (GIP-R) agonists, dual GLP-1R/GIPR agonists, GLP-1R/GIPR/Glucagon receptor (GCGR) triagonists, and oxyntomodulin (OXM), have been shown to improve outcomes of T2DM in a series of preclinical trials ( Table 1 Characteristics of GLP-1 RAs that have been approved to treat type 2 diabetes as of 2021, modified from Li et al

However, along with the rapid titration schedule came gastrointestinal side effects, especially nausea and vomiting, which were the most common reason for discontinuation

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doi: 10.1016/j.obpill.2024.100122 [DOI] [PMC free article] [PubMed] [Google Scholar] 47