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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

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This metabolic shift happens because semaglutide slows gastric emptyingthe rate your stomach releases food into your intestinescreating prolonged fullness signals

doi: 10.1007/BF02427280 29 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW