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Owing to its high surface area and metabolic activity, trabecular bone is highly sensitive to rapid hormonal and nutritional fluctuations, making it initially more susceptible to CR-induced remodeling alterations

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Whilst retatrutide itself is not yet available, understanding who might be considered for peptide-based weight loss treatment in the future and who is currently eligible for approved agents is clinically relevant

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim K-S, Gutierrez-Aguilar R, Li B, Drucker DJ, DAlessio DA, Seeley RJ, Sandoval DA

Lower food intake means lower mineral intake, decreased gut biodiversity, and lower absorption rate