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Whilst mild cold sensitivity is generally expected with weight loss on GLP-1 therapy, certain symptoms warrant medical review to exclude underlying conditions or complications requiring intervention

Mack I, lschlger S, Sauer H, von Feilitzsch M, Weimer K, Junne F, et al

Semaglutide is contraindicated at all doses during pregnancy because animal studies have shown fetal developmental concerns and there are no human safety trials

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-epsilon pathway and modulated by endogenous H2S

Incretin-based medications and other anti-obesity medicines target hunger, therefore fostering both weight loss and weight loss maintenance

Ginger tea can be particularly soothing, as it has natural carminative properties that help expel gas and settle the stomach