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Indeed, Punjabi et al

Mimicking the initial multiple, extensive interactions with the ECD seemed implausible to achieve with smaller, non-peptide molecules

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The ongoing SURPASS-CVOT trial (ClinicalTrials.gov registration no

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor-Deficient Mice

If the patient does not tolerate a specific dose during the dose escalation period, consider delaying the dose escalation for 4 weeks