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Most off-label weight patients titrate to 1 mg or 2 mg rather than the 2.4 mg Wegovy maintenance, and report 8 to 12% body-weight reduction over 9 to 12 months slightly below the published Wegovy figures but well above placebo

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Stimulation of 5-HT2A receptors in the paraventricular hypothalamus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor

Thus, further studies are needed to better elucidate the effects of different GLP-1R agonists on anti-inflammatory actions in depression

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