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GLP-1 signaling also suppresses microRNA-23a, a negative regulator of PGC-1, while upregulating the expression of uncoupling protein 2 (UCP2) for additional protection against oxidative stress [32,33]

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Although Tirzepatide was initially developed to treat type 2 diabetes mellitus, its effectiveness in aiding weight loss for individuals with obesity has become an increasingly important area of interest

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