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An early divergence of the time-to-first-event curves within three months of treatment initiation in SELECT means that the onset of semaglutides cardiovascular benefits preceded most of the achieved weight loss or other changes to cardiometabolic risk factors [91]

The drug recently showed very promising early Phase II data in MASH, a liver disease closely associated with obesity

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2,3 In addition to these mechanisms, GLP-1 RAs also delay gastric emptying, thereby contributing to enhanced postprandial glucose regulation and increased satiety, ultimately supporting reduced caloric intake and weight management

Role of homocysteine in the development of cardiovascular disease