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Clinical Risk Factors: Who Should Avoid or Limit This Combination Certain patient profiles face elevated risk

GLP-1RA can induce glucose-dependent stimulation of insulin secretion, reduce glucagon release, reduce hepatic glucose output, delay gastric emptying and increase satiety, resulting in moderate reductions in glycated hemoglobin (HbA1c), body weight and systolic blood pressure, the risk of hypoglycemia is lower

However, certain risks warrant consideration

For someone on tirzepatide who is adjusting their diet and increasing physical activity, these effects could meaningfully improve body composition outcomes

instead, the goal shifts to preventing excessive weight gain while ensuring adequate nutrition for fetal development