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Description
Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28
The enzyme recognizes alanine at position 8 as a cleavage site and cuts the peptide chain right there, rendering the hormone inactive within minutes
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Diabetes 2023;72(Supplement 1):51OR
Should you have a history of problems with either your kidney or pancreas, it is recommended that you avoid this medication too
If your GP agrees you are eligible, they may use the NHS e-Referral Service to refer you to a specialist weight management clinic
