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Pharmacokinetics of GLP-1 Receptor Agonists Native GLP-1 has limited clinical applications due to its labile nature, with rapid degradation by the dipeptidyl peptidase-4 (DPP-4) enzyme contributing to a short plasma half-life of two minutes [17]
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How long GLP-1-related constipation lasts largely depends on the dose and the individual, says Hamilton
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