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Introduction Proton pump inhibitors (PPIs) are currently the most widely used acid-suppressive agents and are the first-line therapy for gastric acidrelated disorders, such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Barretts esophagus (Freedberg et al., 2017)

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Engineer ND, Kimberley TJ, Prudente CN, Dawson J, Tarver WB, Hays SA