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Sources New England Journal of Medicine: Once-Weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine: Tirzepatide Once Weekly for the Treatment of Obesity Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics: Semaglutide for the treatment of overweight and obesity: A review JAMA Network: Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity American Diabetes Association: Standards of Medical Care in Diabetes, 2025 Harvard Health Publishing: GLP-1 diabetes and weight-loss drug side effects: Ozempic face and more University of Illinois Chicago: What efficacy data are available on the use of tirzepatide for obesity

Heme oxygenase-1 and anti-inflammatory M2 macrophages

Semaglutide, Weight Loss, and Long-Term Success Despite potential side effects, semaglutide remains one of the most effective and clinically supported medications for medical weight management

However, the incidence of ED in males who take semaglutide needs further study

7.4.2 Vascular cognitive impairment Given the strong indication of reduced risk of vascular dementia, dedicated trials are necessary to evaluate semaglutide in patients with established vascular cognitive impairment or those at high risk