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In the consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE), GLP-1 RA is recommended as monotherapy in individuals with HbA1c 1% and weight reduction 3% e Compared to placebo f Compared to other incretin mimetics g Compared to exenatide and liraglutide h Compared to other therapies i Compared to comparator drugs j Compared to exenatide formulations and albiglutide Body Weight and Composition GLP-1 RA decreases gastrointestinal motility and hence increases the time for nutrient absorption

The muscle loss happens because of how you lose weight on GLP-1 medications

A GLP-1 receptor agonist, Semaglutide has emerged as a transformative therapy for Type 2 diabetes and weight management, driven by strong outcomes in glycemic control and weight reduction, it said

Compared with the other medications, people taking the GLP-1 drugs had a reduced risk for addiction: 18 per cent for alcohol, 14 per cent for cannabis, 20 per cent for both cocaine and nicotine, and 25 per cent for opioids

158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects