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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Greenway FL, Fujioka K, Plodkowski RA, et al

Only 12.5% achieved 10% weight loss, while 22% gained at least 10%
Zepbound carries a boxed warning regarding the risk of thyroid C-cell tumors, based on rodent studies showing increased incidence of medullary thyroid carcinoma

Monitoring as Metabolic Control Since many relevant metabolic perturbations remain subclinical, monitoring becomes a proactive control strategy rather than a purely diagnostic measure
If a patients eGFR is less than 60 mL/minute, adjust the dosing
Compounded versions typically come in vials (requiring a syringe for injection) and cost significantly less than brand-name versions
