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Direct cortisol-lowering is not semaglutide's primary mechanism, but clinical observations suggest GLP-1 activation may normalize cortisol's diurnal rhythm and reduce stress-induced cortisol spikes

& Sheikh, S

Most episodes are mild and resolve, but persistent symptoms need workup

While GLP-1 therapies alone have a low risk of causing low blood sugar, adding insulin or sulfonylureas to the mix calls for careful dosage adjustments and close monitoring

Key takeaways Many Kaiser Permanente insurance plans will cover Ozempic when its medically necessary for diabetes, but they may have prior authorization requirements