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PubMed PMID: 34168620

These features may indicate underlying conditions requiring investigation, such as nutritional deficiencies, endocrine disorders (particularly hypercortisolism), or connective tissue diseases

But one such factor is increased intracranial pressure in the head, according to the study researchers

Waiting means delaying obesity treatment by 1824 months

Putting it all together GLP-1 medications provide clear benefits for many people, particularly in the treatment of type 2 diabetes, cardiometabolic disease, and obesity

So, while there are recommended limitations to its use, aspartame consumption according to the FDA is likely safe for those consuming far less than the established ADI