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Morroniside, a GLP-1R agonist, reduced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner in a rat model of neuropathic pain, with peak effects within 1 h and lasting over 4 h [38]

Secondary outcomes included: monthly headache days, headache severity and monthly analgesia days, logMAR visual acuity measured using the Early Treatment Diabetic Retinopathy Study (ETDRS) charts

The FDA approval comes amid growing discussion about the potential uses of weight loss drugs beyond treating obesity and diabetes

Clinical data suggests oral tirzepatide achieves approximately 15% bioavailability compared to injected doses, meaning higher oral doses are needed to match injectable concentrations

[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Chan E

Je komt (nog) niet in aanmerking voor een operatieve ingreep, zoals een maagverkleining