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doi: 10.1016/j.apjtb.2016.08.006 123 GuptaRMathurMBajajVKKatariyaPYadavSKamalRet al

In the brain, impaired insulin signaling alters phosphorylation of insulin receptor substrate (IRS) proteins in the substantia nigra, disrupting mitochondrial proteins, calcium homeostasis, and mitochondrial biogenesis [26-30]

Bell GI, et al

While most of the cancer-preventing benefits seem to come from the drugs reducing obesity a risk factor for over a dozen forms of cancer the findings also suggested that the drugs have anti-inflammatory effects that can stymy cancer development and even suppress tumors

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