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Different hypotheses are considered, including a compensatory relationship between incretin receptors by which GIPR enhances GLP-1R activity and/or that chronic GIPR agonism produces desensitisation and loss of GIPR activity, thus, mimicking antagonism

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This overlap can intensify common side effects associated with GLP-1 receptor agonists, including nausea, vomiting, diarrhoea, abdominal discomfort, and constipation

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Dalle S, Burcelin R, Gourdy P