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This medicine is made in licensed U.S

doi: 10.1210/en.2008-0828 73 KerrBDFlattPRGaultVA

The pattern makes biological sense

doi: 10.1523/JNEUROSCI.6144-08.2009

Among these, diosgenin (a steroidal saponin) is considered the most bioactive compound, and is known to improve diabetic status by promoting pancreatic -cell renewal and stimulating insulin secretion [114]

While GLP-1 receptors are present in the kidneys and may have mild natriuretic effects, they do not typically cause clinically significant polyuria (excessive urination) in the way that diuretic medications do
