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In addition, GLP-2 treatment reduced crypt proliferation and apoptosis, decreased proinflammatory cytokines (IL-1, IFN-, and TNF-) levels, and increased the level of IL-4

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Nevertheless, the pharmacokinetics of semaglutide were similar in healthy individuals and those with type 2 diabetes in previous reports.9, 26, 27 Finally, semaglutide could not be quantified in urine in the present study using an LCMS/MS assay

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Some key findings from the report include: More than 150 GLP-1 drug candidates, intended for the treatment of multiple indications, are currently either approved or being investigated by pharmaceutical companies