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Dose groups included 0.5 mg, 1 mg (escalation and maintenance), 4 mg (escalation from 2 mg), 8 mg (escalation from 2 to 4 mg), and 12 mg (escalation from 2 to 4 to 8 mg)

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To further evaluate which specific HDAC inhibition recapitulated this enhancement of GLP-1R expression in hepatocytes, we used four types of specific HDAC inhibitors, which all belonged to class I HDACs

Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]

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