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There are several reasons for this: Biochemical Effects: Improved insulin regulation and reduced systemic inflammation may directly influence mood-regulating neurotransmitters
Savva A, Kanni T, Damoraki G, Kotsaki A, Giatrakou S, Grech I, et al

current evidence indicates that GLP-1 R expression is found predominantly within the ganglion cell layer (GCL), exclusively detected in a discrete subpopulation of neurons [37]

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