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doi: 10.1038/nature04290 72 FlorioM.HuttnerW

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One potential explanation for this finding is the high levels of stress-induced alterations in gene expression (e.g., increased expression of mitochondrial transcripts) within this subcluster

And theres a lot of work to be done, as you mentioned, in aging and in diabetes because even though part of our clinical population was diabetic, our mice werent

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Obesity (Silver Spring) 31:111122 Jastreboff AM, Aronne LJ, Ahmad NN et al (2022) Tirzepatide once weekly for the treatment of obesity