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PMID: 29099763

GLP-1 Receptor Signalling Augments Glucose-Mediated Insulin Release The Relationship of GLP-1 and Glucose In addition to triggering insulin secretion directly through the above-described series of events, ingested glucose also stimulates the transcription and release of the insulin secretagogue, GLP-1 (figure 5) [65]

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Once your BMI is between 22-24, you should ideally be at the lowest dose of medication

Whilst diarrhea occurs in up to 20% of patients treated with GLP-1RA, 118 national registry studies from Denmark, 89 Israel, 92 and the USA, 93 collectively involving over 10 000 patients with IBD, found no indication that GLP-1RA use was associated with worsening of IBD symptoms or increased adverse event rates

Most blood pressure and cardiac medications do not directly contraindicate semaglutide, but semaglutide-induced weight loss may require adjustment of dosages for hypertension or heart failure drugs