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In this Review, the authors discuss guideline-directed medical therapy for diabetic kidney disease and the evolving clinical evidence for next-generation therapies, including incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory therapies.

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Darien Sutton discusses the two new studies that show certain weight loss drugs can reduce major cardiac events and people consuming less alcohol.