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First, mutations at positions 14 and 17 stabilize the central helix through a salt bridge

It slows the emptying of food contents from the stomach
In doing this, it also causes the stomach to slow down gastric emptying and can simulate a feeling of fullness

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Some insurance companies now include Zepbound as a covered benefit for eligible patients

The result is additive appetite suppression: two signals telling the brain you are full through two separate circuits
