glp 1 agonist benefits GLP-1 Receptor Agonists in Heart Failure Management GLP-1 Agonists: Dual Benefits for

doi: 10.1016/S0140-6736(18)32261-X 15 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

The title of this landmark paper was Preproglucagon Gene Expression in Pancreas and Intestine at the Level of Posttranslational Processing. However, the key finding was, It appears that GLP-I (1-37) may be a 'prohormone' or precursor for GLP-1 (7-37). This rather understated conclusion encapsulates the key discovery that ultimately made the revolutionary new treatments for metabolic disease possible

Back Marso, SP, Daniels, GH, Brown-Frandsen, K, et al (28 July 2016) 'Liraglutide and cardiovascular outcomes in type 2 diabetes', New England Journal of Medicine , 375/4, 311-22

If four weeks pass with zero perceptible effect, consider a small increase to 1 mg rather than jumping to 2 mg

Many GLP-1RAs are modified at this position to provide protection against DPP-4 degradation

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