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[1] [5] Why Menstrual Changes May Occur During Weight Loss Treatment Significant weight loss, regardless of the method used to achieve it, can have profound effects on reproductive hormones and menstrual function

However, most people find that having coffee with food or after eating small amounts of protein significantly reduces any negative effects

References: Jastreboff AM, Aronne LJ, Ahmad NN, et al

Think of meal replacements as a convenient supplement to, not a substitute for, a balanced diet