is glp-1 Drug Side Effects May Be Tackled with More Mechanistic Studies GLP-1 receptor agonists | How

Ten commissioners voted to nix GLP-1 drug coverage for weight loss, aligning with a benefit change already embraced by commercial insurers and the Massachusetts Interlocal Insurance Association

10 or 15 mg once weekly) vs Reduce to tirzepatide 5 mg once weekly vs Placebo for 52 weeks (randomized 3:3:2 at week 60) Primary outcome: Percent change in bodyweight from baseline to week 112 Results: Primary outcome (percent change in bodyweight at week 112): Tirzepatide MTD -21.9%, Tirzepatide 5 mg -16.6%, Placebo -9.9% (estimated treatment difference vs placebo -12.0% for MTD and -6.6% for 5 mg

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It May Have Fewer Side Effects The most common side effects of GLP-1 drugs are gastrointestinal issues such as nausea, diarrhea, vomiting and constipation

The safer choice depends on contraindications, other medications, diabetes treatment, gastrointestinal history, pregnancy considerations, and individual tolerance

Bradshaw HB, Walker JM