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Although epiploic appendagitis has not been identified as an adverse event signal in randomized trials, systematic reviews, or pharmacovigilance reports of GLP-1/GIP receptor agonists, this observation highlights a biologically plausible temporal relationship that may be related to abrupt changes in visceral adipose tissue and regional perfusion

Oral formulations of GLP-1 agonists, including oral semaglutide and oral tirzepatide , create different pharmacokinetic profiles than injections

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