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Our studys emphasis on direct cardiac and hepatic mechanisms, independent of significant weight loss, strengthens the rationale for exploring lower doses of GLP-1RAs in these diverse cardiovascular conditions to potentially maximize benefits while minimizing metabolic side effects

Additionally, GLP-1 receptors in the brainstem's area postrema, a region involved in detecting toxins and triggering the vomiting reflex, may contribute to nausea when activated

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Switching between GLP-1 agents specifically to resolve dry mouth is unlikely to help, though individual responses vary