glp 1 gip glucagon triple agonist Targeting GLP-1, & GCG in Obesity and Type 2 Diabetes Research Science Behind GLP 1 GIP

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Fishbein M.H., Mogren C., Gleason T., Stevens W.R

Regulation of androgen synthesis affects follicular development and ovarian function through multiple pathways: Androgen-promoting pathways: IRS-PI3K/cAMP/PKA, MAPK/ERK (via FGF13/LH/CYP17), NF-B (via TNF- activation/CYP17 up-regulation), and miR-130b-3p (targeting MAPK1/PI3K) all promote androgen production

doi: 10.1038/s41467-020-18262-6 33 LiuKLHeXHuangJYYuSMCuiMTGaoMYet al

We did not perform specific analyses excluding women with a history of bariatric surgery, and we cannot exclude that this may have influenced the results for a small subgroup

But understanding that the labels reflect an absence of data rather than the presence of danger is important context for any mother evaluating her options with her healthcare provider