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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys and humans (reviewed in Barrera et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

Approved Uses: Ozempic is primarily prescribed for managing type 2 diabetes but also has weight loss benefits

Cost sensitivity is a leading driver of medication abandonment across chronic conditions, including obesity and diabetes 4

Within this context, Lillys meticulous R&D strategy and market execution have paid off: Mounjaro and ZepBound are generating record sales, and Lillys pipeline is deep with next-generation incretin candidates

EFSA Journal

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