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Peer review Peer review information Nature thanks Dipender Gill, Ruth Loos and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Clinical trials with GLP-1 receptor agonists consistently demonstrate significant weight loss, with higher doses (such as semaglutide 2.4 mg weekly) producing approximately 15% average weight loss in adults without diabetes in clinical trials (somewhat less in type 2 diabetes) when combined with lifestyle modification

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