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Peer review Peer review information Nature Medicine thanks Johnny Ludvigsson, Judy Zhong and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Some clinical and preclinical studies have demonstrated that the contribution to cardiovascular protection of GLP-1 RAs is mainly ascribed to its modest reduction of blood pressure [33], correction of dyslipidemia [34], improvement of microvascular function [35, 36], and anti-oxidization or anti-inflammation [1, 37]

By targeting both receptors, Mounjaro can potentially offer a more comprehensive approach to blood sugar regulation and weight loss

Obesity-prone rats have normal bloodbrain barrier transport but defective central leptin signaling before obesity onset

In clinical trials of Wegovy HD, most people who developed dysesthesia or altered skin sensations recovered

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