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Notable exceptions include: [1] Patients with C1 esterase deficiency (in whom C1-esterase concentrate is preferred)

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Firstly, expanding indications is a current hotspot in GLP-1 drug research

This seems to be true

Orlistat, a well-known peripherally acting drug, exemplifies this class
Individuals presenting with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should seek alternate treatments
