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Description

In Phase 1 studies, survodutide was generally well tolerated, with no significant safety or tolerability issues observed in either healthy individuals with overweight or obesity [87, 88]

However, the relevance of these findings to humans remains uncertain because human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells, suggesting potentially different susceptibility to GLP-1-mediated effects

This post covers what the Bridge is, who qualifies, how it interacts with Medicares existing GLP-1 coverage for cardiovascular risk reduction, and how it connects to the previously-announced BALANCE Model

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Recombinant GLP-1R analogs with improved pharmacokinetics and sustained action are successful in the treatment of type-2 diabetes, and there is considerable and ongoing effort to further optimize their action profile to improve therapeutic outcome and patient compliance