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In clinical studies of FDA-approved semaglutide for weight management, participants using the medication alongside lifestyle changes experienced meaningful weight loss compared to placebo groups

doi: 10.1038/s41380-020-0697-5

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Food & Drug Administration (FDA)

As our findings are based on good-quality studies that were all multinational double-blind randomized placebo-control trials and our meta-analysis was based on a mean follow-up of 3.45 years (minimum 1.5 year maximum 5.4 years), the confounding and attrition bias are controlled, so the risk of unreliable results is diminished

Diagnostic Evaluation of an Increased Risk of Developing Small Intestinal Bacterial Overgrowth Associated with Glucagon-like Peptide-1 (GLP-1) Receptor Agonists and Dual GLP-1/GIP Receptor Agonists: A Global Retrospective Multicenter Cohort Analysis