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It is prescribed

Sacubitril/valsartan has demonstrated consistent benefits not only in HF with reduced ejection fraction (HFrEF) but also in selected patients with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), especially women and those with borderline left ventricular ejection fraction, as shown in the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) and Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction (PARAGON-HF) trials and supported by Indian ARNI PRESERVED study

This surge coincided with Zepbounds approval for OSA, marking the largest observed difference in uptake between patients with and without a comorbidity

Clinically, that translates to: More stable post-meal glucose Better appetite regulation Reduced energy crashes Improved satiety Mechanistically: GLP-1 slows gastric emptying, signals fullness centrally, supports insulin secretion, and suppresses glucagon

Pharmacist-led support for provider-directed care.

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