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Additionally, loss of muscle mass during rapid weight loss can reduce the efficiency of muscle pumps that help return blood from the extremities to the heart, leading to blood stasis, particularly in the legs, which is a risk factor for deep vein thrombosis (DVT)

Engstrm A, Wintzell V, Melbye M, et al

However, the authors note that substantial weight loss can be accompanied by reductions in lean body mass, underscoring the need for further research into dosing strategies and interventions that preserve muscle while promoting fat loss

Research shows that miR-27a targets PPAR's 3-UTR

The second variable was to account for possible heterogeneity in the effectiveness within a drug class (for example, for empagliflozin, this variable grouped all patients who used that drug