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This observed lack in the expression of the receptor may be related to the fact that it is necessary to trigger an inflammatory response in the brain to increase its density, which indicates that it plays a role in controlling inflammation [22,91]

According to the MHRA product information, the medication has a long half-life of approximately one week (around 165 hours), which allows it to maintain therapeutic levels in the body between doses

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GLP-1R is expressed in neurons and glial cells throughout the CNS, and GLP-1R activation reduces neuroinflammation and improves synaptic plasticity in animal models