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Potential treatment effect modifiers were also accounted for in the primary analysis by restricting the SURPASS2 population to patients complying with the HbA1c inclusion criterion of SUSTAIN FORTE (referred to as the SURPASS2 refined population)

Tirzepatide and Semaglutide weight loss injections are administered as a subcutaneous injection once a week

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Dual Incretin Signaling# GLP-1R activation : Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite via hypothalamic signaling GIPR activation : Potentiates insulin secretion, may improve lipid metabolism and fat distribution, enhances central appetite regulation Synergistic effects : The combination produces greater glycemic and weight effects than either pathway alone Pharmacokinetics# The C20 fatty diacid modification enables albumin binding, yielding a half-life of approximately 5 days and supporting once-weekly administration

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Talk to your doctor if youre concerned about any symptoms or side effects when taking Mounjaro.