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Retatrutide adds the "output" side

H., Hoffmann K., Allen N., et al., Body Size and Breast Cancer Risk: Findings From the European Prospective Investigation Into Cancer and Nutrition (EPIC), International Journal of Cancer 111 (2004): 762771
Consequently, current guidelines suggest the use of GLP-1RAs for patients with a history of atherosclerotic vascular disease (23)

Over 10% of study participants with eating disorders misused the GLP-1

Surveys indicated significant public awareness

In clinical studies treatment with liraglutide was associated with an increase in HR (mean difference 7 bpm) and more serious cardiac adverse events (3% vs 10% for placebo and liraglutide, respectively) in chronic heart failure patients with and without type 2 diabetes (135)
