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The starting dosage for adults is 2.5 mg injected subcutaneously once weekly

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Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)

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15 mg of tirzepatide equals 75 units at a concentration of 20 mg/mL, or 50 units at a concentration of 30 mg/mL

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Patient-specific factors include age (older adults have more fragile blood vessels and thinner skin), genetic predisposition to easy bruising, nutritional status, and underlying medical conditions affecting coagulation or vascular integrity

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