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Primary APP23 mouse neurons were infected with lentivirus carrying scramble sequence or short-hairpin RNA (shRNA) sequence targeting AMPK, with or without treatment of exendin-4

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Using paired peripheral-blood methylomes collected at baseline and 32 weeks, we conducted a post-hoc analysis spanning 17 first-, second-, and third-generation DNA-methylation clocks

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Accompanying symptoms such as nausea, vomiting, and fever strengthen this concern